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The general downregulation of these genes suggests that H3Q5dop functions by maintaining the cocaine-induced pro-relapse transcriptional program 107

For perimenopause specifically, hormonal fluctuation drives many of the most disruptive symptoms estrogen can spike and crash erratically, which is why some patients feel worse in early perimenopause than in full menopause

[DOI] [PubMed] [Google Scholar] 6.McCully K.S